PLoS ONE 3(3): e1897. doi:10.1371/journal.pone.

A report by the Nuffield Council on Bioethics, contrary to the Declaration of Helsinki, permits most important research initiatives in developing countries.The Ethics of Research Related to Health Care in Developing Countries by the Nuffield Council on Bioethics makes a number of innovative recommendations that depart from codes such as the Declaration of Helsinki. It recommends that standards of care might be relativised to the standard of that nation. It recommends that very good reasons need to be given for not (...) giving post-trial access to medications but recognises that there may be justifiable instances of this. It is the view of the authors that these and other recommendations of the report are sensible pieces of advice given the complexities of the developing world. (shrink)

Biologically, pain is neither intrinsically good nor bad, but is a communication mechanism designed to serve organismal ends. Pain for any given person at any given time should be evaluated on the basis of “success” (or not) in serving those purposes. Yet, the physiological, psychological, and cultural complexity of the experience makes moral consideration of pain complicated. This is especially the case with infants in pain. The competence of the infant as a “decision maker” cannot, of course, be assumed. Even (...) if the child “thinks” about pain, an epistemological barrier exists in that the child cannot clearly communicate about the pain experience. Furthermore, any expressions of pain from the child may be necessary for diagnosis. Just coercion criteria provide a means of evaluating when and to what extent pain in infants should be controlled under the authority of surrogate decision makers. (shrink)

The object of this article is to examine the letter from which Plutarch quotes in the above passage from the twenty-eighth chapter of his life of Alexander; to attempt to prove, particularly by a comparison of the letter with the Sidypafifia sent in 319 B.C. by Polyperchon to the Greek cities, that it is a genuine part of Alexander's correspondence; and further to consider what light the letter, if genuine, throws upon the person of Alexander himself.

Economic models are founded in the idea of taking individuals' preferences as both known and given. This article explores the evolution of personal preferences, within a context of both entrepreneurial discovery and Objectivist philosophy. It begins by formalizing Ayn Rand's theory of Objectivism applied to human values, and continues by modeling preference changes similar to Schumpeter's theory of creative destruction—a process of self-discovery. Next the role of societal factors is examined in forming shared preference sets. Finally, the article describes how (...) the strength of human preferences is used to narrow choice sets in the presence of greater consumption options. (shrink)

The text of lines 39–40 is open to three main objections: stimulantem pectu Achilli cannot be construed in its context; to refer tuas to Persen would involvi difficult, though not unexampled, change of person; and thirdly, and most serious, it is scarcely possible to believe that Cornelia could appeal to a king of Macedon to testify to the soundness of her morals.

This article presents the Pilgrimage Model as a template for educators wishing to lead students on site-specific studies of engaged learning. During the 2015–2016 academic year, a group of Georgeto...

O objetivo é propor uma reconstrução racional da concepção da ciência de Duhem, por meio do recurso da metodologia da teoria da ciência, como uma teoria normativa da dinâmica do conhecimento. Essa reconstrução ajuda a estabelecer que Duhem não pode ser classificado como um convencionalista/pragmatista, como sugere a interpretação-padrão, e, além disso, que Duhem almeja construir uma concepção que seja um termo médio entre a concepção metafísica clássica e a concepção do convencionalismo/pragmatismo. A estratégia metodológica para construir esse termo médio (...) é a proposta de um realismo estrutural e convergente. Duhem substitui o sujeito transcendental dos clássicos por uma teoria transcendental a ser alcançada por um processo dinâmico. Using the resources of the methodology of theory of science we propose a rational reconstruction of Duhem's conception of science, interpreting it as a normative theory of the dynamics of knowledge. Such a reconstruction helps to establish that Duhem cannot be classified as a conventionalist/pragmatist as proposed in the standard interpretation, and, furthermore, that Duhem proposes to construct a conception of science as a middle way between a classical metaphysical conception and a conventionalist/pragmatist conception. The methodological strategy for this middle way is the proposal of a structural and convergent realism. Duhem replaces the transcendental subject of the classics with a transcendental theory to be reached by a dynamic process. (shrink)